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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Sulforaphane, Gemcitabine
Phytochemical Name Sulforaphane (PubChem CID: 5350 )
Anticancer drug Name Gemcitabine (PubChem CID: 60750 )
Structure of
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Structure of
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02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 902
Ref_1
Pair Name Sulforaphane, Gemcitabine
Disease Info [ICD-11: 2C12] Hepatocellular carcinoma Investigative
Biological Phenomena Induction-->Blockade of cell cycle in G2/M phase
Gene Regulation Up-regulation Expression BAX hsa581
Down-regulation Expression BCL2 hsa596
Up-regulation Expression CDKN1A hsa1026
Up-regulation Phosphorylation CHEK2 hsa11200
Down-regulation Phosphorylation CDC25C hsa995
In Vitro Model HuCC-T1 Intrahepatic cholangiocarcinoma Homo sapiens (Human) CVCL_0324
HuH-28 Intrahepatic cholangiocarcinoma Homo sapiens (Human) CVCL_2955
In Vivo Model A million cells were suspended in 200 μL of medium containing Matrigel (Corning, Tewksbury, MA, USA; 1:1), and the same type of 1×10⁶ cells was inoculated subcutaneously into the bilateral flanks of each mouse.
Result Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity
03. Reference
No. Title Href
1 Sulforaphane Potentiates Gemcitabine-Mediated Anti-Cancer Effects against Intrahepatic Cholangiocarcinoma by Inhibiting HDAC Activity. Cells. 2023 Feb 22;12(5):687. doi: 10.3390/cells12050687. Click
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